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A study revealed that L-methionine supplementation (1.7 g/kg/day, P.O for 8 weeks) was sufficient to produce hyperhomocysteinemia in rats and markedly increased the mean arterial pressure, oxidative stress and mean cardiomyocyte diameter [107]

doi: 10.1152/ajplung.00244.2018 22 LaGoryELWuCTaniguchiCMDingCCChiJTvon EybenRet al

Ca 2+ is implicated in the regulation of neurotransmitter release from presynaptic nervous terminals