Tirzepatide is a medication that improves insulin sensitivity, which can be evaluated indirectly through fasting biomarkers such as glucose and insulin and the homeostasis model assessment of insulin resistance (HOMA2-IR)
doi: 10.1111/j.1476-5381.2011.01687.x 57 MllerTDFinanBBloomSRD'AlessioDDruckerDJFlattPRet al
So, yes reduction of body fat mass while maintaining or building lean body mass is possible, which involves resistance training, an individualized healthy rate of fat loss, macronutrient / calorie modulation, high protein, supplements / nutraceuticals, plenty of low carb vegetables, etc
Bax then translocates from the cytoplasm to the outer mitochondrial membrane, where it oligomerizes to form channels (63)
The comparison isn't either/or but rather understanding how different peptide classes can work together