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In patients with MASLD and established CVD, GLP-1-based therapies are strongly supported as a cornerstone treatment addressing both hepatic and cardiometabolic disease burden simultaneously

But true receptor downregulation through lysosomal degradation requires the cell to synthesize entirely new receptors, a process that takes considerably longer

Simultaneously, tirzepatide suppresses glucagon secretion, which decreases hepatic glucose production

It has been studied in research settings for its ability to stimulate the pituitary glands natural growth hormone release pathway

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