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Gastrointestinal Adverse Reactions In the pool of placebo-controlled trials, gastrointestinal adverse reactions occurred more frequently among patients who received semaglutide tablets than placebo: semaglutide tablets 14 mg once daily (41%), semaglutide tablets 7 mg once daily (32%) and placebo (21%), including severe reactions (semaglutide tablets 14 mg 2.0%, semaglutide tablets 7 mg 0.6%, placebo 0.3%)

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Both prescription semaglutide and natural alternatives that affect GLP-1 activity require careful consideration of safety, contraindications, and appropriate medical supervision

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Shima Hadidchi, MD Who Should Consider Oral Semaglutide