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Correspondingly, the inhibition of NF-B by BAY 11-7082 significantly increased the survived SGN numbers, while decreased the C-CASP3 positive SGN numbers and the C-CASP3 expression in peroxynitrite + BAY 11-7082 group compared with the peroxynitrite group (Figures 9DF)

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Hence, the ongoing FLOW trial (NCT03819153) is assessing the effects of semaglutide on complex renal outcomes in patients with diabetic kidney disease [265]