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In this experiment, the high protein diet can promote intestinal secretion of GLP-1, improve FGF21 resistance, upregulate LKB1 to activate the AMPK pathway, downregulate the expression of SERBP-1c mRNA and protein in the liver, and ultimately inhibit liver lipid synthesis [50]

If the research goal is more systemic, the timing becomes slightly less critical, but an empty stomach is still generally preferred to maximize absorption potential

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Niacinamide (Vitamin B3) blocks melanosome transfer from melanocytes to keratinocytes, providing additional pigment-evening effect, and strengthens the epidermal barrier