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55-58 Preliminary results of the Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE) study, a long-term multicenter trial on the effects of calorie-restricted diets in healthy overweight volunteers, 59 showed moderate calorie restriction can reduce several cardiovascular risk factors (LDL cholesterol, triglycerides, blood pressure, and C-reactive protein)

Estimation of vitamin C intake requirements based on body weight: implications for obesity

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Moreover, clinical trials using traffic violations or accidents as outcomes face major ethical and methodological barriers, including safety concerns and large sample size requirements