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Timeline of Weight Regain After Discontinuing Semaglutide In the first 14 weeks after stopping semaglutide, most patients notice a sharp increase in appetite and food cravings, but weight change is minimal because the drug is still clearing from your system

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Increased GLP-1R signaling promotes the phosphorylation and translocation of aquaporin 4, which may facilitate A efflux clearance from the brain parenchyma by increasing intracerebral water flux (Sasaki et al., 2024)

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