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ActRII: activin type II receptors, T2D: type 2 diabetes, 6 MWD: 6-minute walk distance, GLP-1/GIP: glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide, SARMs: selective androgen receptor modulators, DMD: Duchenne muscular dystrophy, GLP-1RAs: GLP-1 receptor agonists, IGF-1: insulin-like growth factor, CV: cardiovascular Conclusions Skeletal muscle wasting is a frequent and clinically significant complication in patients with T2D and obesity, which is exacerbated by chronic inflammation, insulin resistance and metabolic dysregulation