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It acted via non-competitive inhibition, binding to non-active sites and inducing structural rearrangements, with reduced -helical content and increased -sheet and random coil, thereby disrupting ACE function without active-site competition

Some doctors have prescribed them for decades off-label, or for unapproved uses, in patients with gastric ulcers, nervous system disorders and other conditions

As the key enzyme of the pentose phosphate pathway, G6PDH generates NADPH, which is essential for fatty-acid and steroid biosynthesis (Zhou et al., 2020)

This stacking concept is explored further in the stacking strategies section below