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Acute overdose can result in hepatic toxicity, and in some instances- fulminant hepatic failure

however, T-cell receptor (TCR)-stimulated activation increases the expression of the Myc transcription factor, glutamine transporters (SLC38A1, SLC38A2), and glutaminolysis-related enzymes (GLS, GLUD1, GOT, GPT) to meet bioenergetic and biosynthetic requirements, resulting in T-cell proliferation 130,131,132,133

It also lacks regional data, so you wont know where your muscle or fat is distributed

They may help as an adjunct, especially if gut health is compromised and endogenous DAO release is low