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Common side effects of tirzepatide include nausea (affecting 24-29% of participants in trials), diarrhea (18-24%), vomiting (8-10%), and constipation (16-17%)
Individual genetic variation in insulin receptor sensitivity and gluconeogenic capacity influences how effectively these pathways coordinate
( a ) Schematic of BDH1- and OXCT1-mediated ketolysis
Lastly, managing cravings and appetite increase, which may return after withdrawal, is a key area of future pharmacotherapy
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