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That is basically a 27 BMI (body mass index) and a weight-related comorbidity, or a 30 BMI and above. Comorbidities include type 2 diabetes, hypertension, dyslipidemia, heart disease, osteoarthritis, obstructive sleep apnea, kidney disease and non-alcoholic fatty liver disease

It is possible that, in addition to factors such as reduced alcohol consumption, weight loss-related improvements in body image, or relief associated with better glycemic control in diabetes, there may also be direct neurobiological mechanisms involved, for example, through changes in the functioning of the brains reward system, says Research Director, Docent Markku Lhteenvuo from the University of Eastern Finland

The appropriate Tesofensine dosage can vary depending on several factors, including individual characteristics and specific weight loss goals

| Weight loss: what the evidence shows | Side effects and tolerability | Dosing and practical differences | Cost and access in the UK | Who might prefer each option

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