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Significantly elevated mucosal TPH1 expression in obese humans (38, 39) and elevated levels of circulating 5-HT in individuals with type 2 diabetes (T2D) (4042) or obesity (38) has been reported

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Same nonpeptide allosteric binding mode in that TM1/TM2/TM3/TM7/ECL2 hydrophobic pocket of GLP-1R, but Structure made a clever SAR move with a phosphine oxide motif cleans up the IP while keeping the G-biased signaling profile that matters for oral efficacy