GPR17 agonist treatment had no effect on GPBAR-A-stimulated cAMP levels in the control transduction condition, but there were modest MDL29,951 concentration-dependent increases in cAMP in cells expressing hGPR17L relative to vehicle treatment (Figure 6F)
McCarter (2014) Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients International Journal of Colorectal Disease, 21 October 2014, Volume 29, pages 15271534
Benefits appear consistent across a broad range of subgroups, including those with varying levels of glycemic control and kidney function
World Journal of Gastroenterology, 27 (33), 5555-5565
Cederroth CR, Canlon B, Langguth B