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The bedtime levothyroxine alternative Some endocrinologists recommend switching levothyroxine to bedtime dosing for patients on GLP-1 medications

But I advise against it

The drug enhances insulin secretion from pancreatic beta cells in a glucose-dependent manner, meaning it stimulates insulin release primarily when blood glucose levels are elevated

Medications that require rapid absorption or have specific timing requirements relative to meals may need to be taken at different times of the day