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Berberine is a bitter tasting chemical extracted from the roots of plants, such as goldenseal and barberry

[DOI] [PubMed] [Google Scholar] 99.Petrovic I., Dobric I., Drvis P., Shejbal D., Brcic L., Blagaic A.B., Batelja L., Kokic N., Tonkic A., Mise S., et al

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5 The annual incidence ranges from 8.8 to 23.1 per 100,000 person-years in North America, 0.624.3 per 100,000 person-years in Europe, and 7.317.4 per 100,000 person-years in Oceania, with a prevalence in adults in their 30 s and 40 s