It upregulates genes involved in collagen synthesis (COL1A1, COL3A1, COL5A1), extracellular matrix remodeling (decorin, fibromodulin), and antioxidant defense (superoxide dismutase, glutathione peroxidase) while simultaneously suppressing genes associated with inflammation (IL-6, TNF-alpha), fibrinogen production, and tissue destruction (several MMPs)
Chloramphenicol Effect: May reduce the effectiveness of Vitamin B12 in red blood cell production
B12 may be injected into a muscle or beneath the skin at 100 mcg every day or alternate days for 7 days, and then every 3 or 4 days for a month
S-adenosylmethionine treatment of depression: a controlled clinical trial
1 Physiological changes occur in the second trimester, increasing plasma volume alongside a smaller increase in red cell mass resulting in haemodilution recognised as physiological anaemia