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What Retatrutide Is: A Triple-Receptor Agonist Built for Weight and Glucose Retatrutide is a once-weekly, subcutaneously administered synthetic peptide engineered to activate three distinct receptors at once: the glucose-dependent insulinotropic polypeptide receptor (GIPR), the glucagon-like peptide-1 receptor (GLP-1R), and the glucagon receptor (GCGR)

12mg weekly dose The highest dose tested produced 24.2% body weight loss at 48 weeks

For type 2 diabetes treatment, tirzepatide (Mounjaro) shows constipation rates of 12-17% across doses, while semaglutide (Ozempic) reports rates of 8-10% at diabetes doses

Your pituitary gland releases GH in pulsatile bursts throughout the day, with the largest pulse occurring 90120 minutes after deep sleep onset