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Si bien estos frmacos no afectan directamente la secrecin de insulina ni la captacin de glucosa en los tejidos, tienen un impacto beneficioso en ambas condiciones al corregir la hiperglicemia y por ende, la glucotoxicidad102,112

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As each dataset has multiple experimental groups, to correct for the variance between studies while preserving variance between cell types and experimental groups, we trained the single-cell variational inference (scVI) model 55 on the control groups from each study with the study as the batch key, and then integrated the experimental groups (Extended Data Fig

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