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GOT1 knockout combined with cysteine depletion by erastin or IKE showed potent antitumor effects against these cells by reducing GSH and increasing ferroptosis 66

Diabetes 57 , 13491354 (2008)

No amount of dietary restriction will fully resolve symptoms if the nervous system is constantly triggering histamine release from within

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In our carnitine-bound structure, we identify a Na + binding site sandwiched between TM1 and TM4 of the N-terminal bundle, which is further housed within an aqueous cavity that extends upward within the N-terminal domain (Figs