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The protective effect of SFN appears to be NRF2-dependent, as NRF2 deficiency exacerbated psoriasis-like symptoms, as well as the inflammatory response and abnormal proliferation of keratinocytes in the mice, and SFN had little therapeutic effect in the IMQ-modeled knockout mice

Not a Standalone Treatment: Like all pharmacotherapies, GLP-1 agonists should be used as part of a multi-modality treatment approach that includes behavioral therapy, lifestyle changes, and social support

[DOI] [PMC free article] [PubMed] [Google Scholar] 8.Seiwerth S., Milavic M., Vukojevic J., Gojkovic S., Krezic I., Vuletic L.B., Pavlov K.H., Petrovic A., Sikiric S., Vranes H., et al