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89 Importantly, restoration of hypothalamic autophagy via nutritional interventions such as docosahexaenoic acid-acylated astaxanthin monoester (AST-DHA) supplementation or genetic activation of Atg5 ameliorates obesity and improves glucose metabolism in experimental models, 90 demonstrating that hypothalamic autophagy is not merely correlative but mechanistically regulatory

Without intrinsic factor, B12 cannot cross the gut wall, and red blood cell production, nerve maintenance, and DNA synthesis all suffer

FIGURE 1 The prevalence of DED, which surged to as high as 61.0% during the COVID-19 pandemic (Ji et al., 2023), underscores the influence of increased exposure to visual display terminals and widespread mask usage during the pandemic, which likely exacerbated the condition by decreasing blink frequency and increasing thermal air currents over the ocular area, thus enhancing tear evaporation rates (Uwimana et al., 2022