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Acknowledgements The authors express their gratitude to Associate Professor, Heba Mahmoud Abood from the Pharmaceutics and Industrial Pharmacy Department at Beni-Suef University in Egypt for her invaluable assistance while preparing the formula

The Nrf2 mRNA data exhibit no significant increase at high concentrations of DEM

Mastitis or other infections can cause localized breast pain, swelling, redness, and sometimes fever

Measurement of intracellular and cell supernatant H 2 O 2 levels For intracellular and cell supernatant H 2 O 2 levels, 143B cells were plated in 6-well plates

All the three exposed groups indicated a gradual increase in the activity of SOD from day 7 to day 30