Many patients taking GLP-1 medications like semaglutide (Ozempic, Wegovy) or tirzepatide (Mounjaro, Zepbound) experience digestive side effects including nausea, bloating, and altered bowel habits
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This case report discusses the use of Semaglutide in a patient with systemic lupus erythematosus (SLE) and comorbid type 2 diabetes mellitus (T2DM)
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4 Discussion The improvement of semaglutide on obese individuals is significant, and the main mechanism of this type of GLP-1RA is to stimulate GLP-1R, triggering activation of several metabolic pathways involved in insulin secretion, lipid metabolism, energy expenditure, cell survival, anti-apoptotic signaling, and oxidative stress prevention in tissues such as the pancreas, central nervous system, heart, muscles, kidneys, and intestines ( We found that intraperitoneal injection of 100 g/kgbw of semaglutide every other day significantly improved the abnormal weight gain induced by a high-fat diet, reduced the proportion of white adipose tissue in the groin and epididymis
