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Treatment of NRAS-Q61L mutated AML cells with the ferroptosis-inducing molecule erastin resulted in enhanced ROS levels and cytosolic translocation of HMGB1 leading to cell death, whereas this effect was not seen in unmutated cell lines (96)

Production of glutathione using a bifunctional enzyme encoded by gshF from Streptococcus thermophilus expressed in Escherichia coli

Additionally, the decreased mitochondrial output creates low motivation which is often misdiagnosed as depression

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