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TMA wird anschliessend vom Darm in die Leber transportiert und dort vom Leberenzym flavinhaltige Monooxygenase 3 (FMO3) in Trimethylamin-N-Oxid (TMAO) umgewandelt

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Metformin inhibits mitochondrial ATP production by inhibition of Complex I of the respiratory chain and/or inhibiting mitochondrial glycerophosphate dehydrogenase, which is required to carry reducing equivalents from the cytoplasm into the mitochondria for re-oxidation (48,49)

It has since been studied in rodent models for tendon healing, gut mucosal repair, and angiogenesis

doi: 10.1016/j.phymed.2022.154182 177 MarkowitschSDSchuppPLaucknerJVakhrushevaOSladeKSMagerRet al