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Oxidative stress alters mitochondrial function by modulating the expression of fusion-fission proteins, including mitofusin-1/2 (MFN1/2), optic atrophy protein 1 (OPA1), and dynamin-related protein 1 (DRP1)

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Caplan tried PT-141 herself years ago when it was still experimental her experience was underwhelming, but the compound eventually completed clinical trials and reached the market under proper regulation

FIS1, the earliest identified mitochondrial junction protein, resides on the outer mitochondrial membrane, where it facilitates mitochondrial fission by engaging in a complex with Drp1