Results: Evidence indicates local estrogen dominance with progesterone resistance, pervasive immune dysregulation, and oxidative stress with iron-driven ferroptosis that particularly injures granulosa cells, alongside disease-relevant genetic/epigenetic regulators and reproductive-tract/gut microbiome dysbiosis
Over the years, disulfide-containing compounds (-SS-) have been extensively explored in the development of GSH-sensitive drug delivery systems (DDSs) [52]
doi: 10.4103/2230-8210.179997 16 ChebotarI
In addition to important role in the folate cycle that is involved in the reduction of BH 2 to BH 4 , it is an important component in homocysteine metabolism via the methionine cycle (Figure 8), and is critical for neural tube development
Bisht S, Faiq M, Tolahunase M, Dada R (2017) Oxidative stress and male infertility