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These agents are associated with classic chemotherapy toxicities such as myelosuppression, mucositis, gastrointestinal disturbances, and alopecia, due to their non-selective activity against proliferating cells

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Indeed, riboflavin suppresses the cortical neuronal endogenous release of glutamate via reduction in the activity of presynaptic voltage-gated calcium channels, inhibiting the exocytosis of glutamate vesicles (Riboflavin as a Determinant of the Kynurenine Pathway. Concerning PD, glutamate excitotoxicity contributes to dopaminergic neuronal loss ( parkin gene encodes an E3 ubiquitin ligase involved in ubiquitin-proteasome pathway

Role of the exchange protein directly activated by cyclic adenosine 5-monophosphate (Epac) pathway in regulating proglucagon gene expression in intestinal endocrine L cells