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Consistent with the major contribution of GIP to the enteroinsular axis of these mice [27], administration of (Pro 3 )GIP, exendin(939)amide or a combination of both peptides lowered the hyperinsulinaemia of fed ( ob / ob ) mice by 20, 27 and 19%, respectively
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Paul AE Gray
Symptoms may include abdominal pain or discomfort as well as altered bowel habits (diarrhea, constipation, or both)
Additionally, senescence induced by glucocorticoid treatment, known to increase DPP4 transcriptionally (79), can be modulated by inhibition of DPP4 activity (80)
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