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Caruso I, Marrano N, Biondi G et al (2023) Glucagon in type 2 diabetes: friend or foe

Major insulin signaling pathways in the brain When insulin binds to its receptor, it activates two major intracellular signaling pathways, which regulate key brain functions, including neurotransmission, metabolism, energy balance, and neuronal survival [Figure 1]

This condition, characterized by dark patches on the skin, occurs when melanin is produced in excess

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The increase in serum melatonin in AD might represent a compensatory mechanism to reduce skin inflammation by attempting to alleviate excessive oxidant production (59)