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When referring to the production of phosphatidylcholine and phospholipids for the cell membrane, this phase is an essential intermediate step that controls the rate at which the process occurs
The N-hexanoic (C-terminal) and 6-aminohexanoic amide (N-terminal) modifications introduced during the lead-optimization phase of the Harding laboratorys Ang IV-analog program were specifically designed to increase hydrophobicity, decrease hydrogen bonding, and improve metabolic stability against the proteases that degrade native angiotensin IV
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