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Retatrutide: How the Triple Agonist Compares to Tirzepatide Quick Answer Retatrutide is a synthetic 26-amino acid peptide that simultaneously activates three receptor pathways: GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon receptors

Koppe, L., Fouque, D

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237 Similarly, KD enhanced the effectiveness of anti-CTLA-4 immunotherapy by reducing PD-L1 protein levels and augmenting the expression of interferons and antigen presentation-related genes

It is crucial for effector T-cell functions through the regulation of metabolic activity and has been linked with the pathogenesis of several autoimmune diseases (109), including psoriasis (110)