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A randomised, double-masked, placebo-controlled trial confirmed that oral glutathione in both reduced and oxidised forms significantly lowered melanin index and reduced visible pigmentation changes over the study period [2]

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It has also been known to appear on the buttocks, thighs, hands, and top of the legs

PBS (177 mM phosphate, 85 mM NaCl, 0.05% (v/v) Tween 20) at pH 5.5 was used as dilution and running buffer, while PBS (195 mM phosphate, 85 mM NaCl, 0.05% (v/v) Tween 20) at pH 7.4 was used as regeneration buffer