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The molecule was developed by the Australian pharmaceutical company Metabolic Pharmaceuticals (in collaboration with Monash University) and advanced through Phase I safety trials and a Phase IIb obesity efficacy trial enrolling approximately 900 participants in total
TB-500 works through Thymosin Beta-4's actin-sequestering domain to regulate cytoskeletal remodelling and promote endothelial migration, with particular documented activity in cardiac tissue
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