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The observation in this study in hepatocytes that protein-SSG formation by either GSSG accumulation or treatment with a direct S -glutathionylation induction agent resulted in IKK--SSG formation, leading to its suppression, was supported by a previous study reporting that S -glutathionylation was associated with suppressed IKK- activity in epithelial cells 41

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These proteins include the E3 ubiquitin ligase RNF26, which forms a complex with several ER cofactors, including TMEM43, endonuclease domain-containing protein 1 (ENDOD1), TMEM33, and transmembrane emp24 domain-containing protein (TMED1)

As water content decreases, the relative concentration of these compounds increases, producing a stronger ammonia-like smell

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