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In this context, we have previously demonstrated that Vitamin C effectively inhibits 3D breast tumor spheroid formation, with an IC-50 of 1 mM, suggesting that this micronutrient also works as an inhibitor of CSCs [13], whose activity is critically dependent on an active mitochondrial TCA cycle and OXPHOS

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Any discussion of preclinical literature, receptor-pathway context, or source language should stay tied to model-specific research interpretation and documentation review.

7.4 Aloe vera The results of a double-blind, randomized clinical trial on melasma patients revealed a 32% improvement in the MASI score for the liposomal aloe vera gel group, while only a 10% improvement was obvious for the conventional aloe vera gel group ( 7.5 Vitamin C The safety and efficacy of topical vitamin C nanosome with iontophoresis was evaluated through a single-blind clinical study and results were compared with 70% glycolic acid chemical peel in patients with melasma

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