Lang, Calvin A., Betty Jane Mills, Helen L Lang, Marica C Liu, Wayne M
Glucose-6-phosphate dehydrogenase deficiency
Recently, the role of this cell death modality in the pathogenesis of various diseases has garnered increasing attention ( activity, depleting intracellular reduced glutathione(GSH), whereas RSL3 directly covalently binds to and inhibits GPX4 activity ( 2.2 The central role of GPX4 in ferroptosis GPX4, a selenocysteine-dependent antioxidant enzyme, occupies an irreplaceable central position in the cellular defense network against ferroptosis
Subcutaneous injections cannot deliver enough red methyl-B12 fast enough to be cleared by the kidney and show red in the urine unless the volumes are huge, significantly greater than any that I commonly use
The study only employed a single drug dose, overlooking dose-dependent investigations, which will also be addressed in subsequent research