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225 The components of the ECM are mainly produced by neurons and astrocytes, and microglia can also regulate the remodeling of the ECM

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The research indicates upregulation of p53-pS15 and p16 maintains a persistent senescent microenvironment that promotes cell cycle arrest and apoptosis resistance in keloid fibroblasts, perpetuating pathological scar formation

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Avoid Extreme Temperatures Extreme hot or cold weather triggers this skin condition and can exacerbate rosacea symptoms, so try to avoid going out in extreme weather conditions