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One cluster analysis of 131 ME/CFS patients diagnosed according to the Fukuda criteria revealed that 34% of patients experienced sympathetic symptoms with dysautonomia (and were associated with more severe disease severity), 5% from sympathetic symptoms alone, 21% parasympathetic, and 40% struggled with sympathovagal balance (331)

Ick +/ retinas compared with that in the Mak +/ retina and that the extent of the decrease in the Mak /

The bioavailability of supplemental 5-methyl-THF has been reported to be similar or higher compared to folic acid at equimolar doses

Animals and housing Following laboratory animal welfare (3Rs: Replacement, Reduction, and Refinement) best practice [31], we acquired 13 adult female mice (C57BL/6 background) from another lab which were excess to experimental requirements, experimentally nave, and slated for euthanasia

This dose has been shown in vivo to be protective in a gastric mucosal lesion model (25) and it has been shown to promote bone healing in rabbits (28)