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Progressive depletion of cellular glutathione is also used as a mechanism by many viruses to control their replication cycle during infection.

446 Astrocytes are fundamental for both excitatory and inhibitory transmission through glutamate glutamate (GABA)-glutamine shuttle 447 and chloride ionostasis 330 and are thus well positioned to contribute to OCD pathophysiology

Indeed, the detailed mechanism and regulatory pathways involving receptor phosphorylation [61, 62], -arrestin binding [63, 64], and internalization [20, 65], resensitization and recycling through dephosphorylation [20, 66, 67] may not only be agonist-selective [6769], but also depends on receptor subfamily, cell and tissue types [20, 70, 71]

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