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Finally, integration into existing wound-care protocols through collaborations with clinicians and industry partners can facilitate adoption

The folate-cobalamin interaction is pivotal for normal synthesis of purines and pyrimidines and the transfer of the methyl group to cobalamin is essential for the adequate supply of tetrahydrofolate, the substrate for metabolic steps that require folate

A narrative review concluded that the practice is controversial because there are no standardized dosing protocols and nearly onethird of patients report adverse effects, ranging from mild gastrointestinal symptoms to liver dysfunction and lifethreatening allergic reactions

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Hormone replacement or modulation (thyroid, prolactin, insulin sensitizers) addresses endocrine-driven infertility