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Early discontinuation may be overestimated if treatment occurred outside the purview of the claims data source 13 KESIMPTA received approval in August 2020, resulting in a relatively limited number of patients with sufficient real-world follow-up data to assess persistence and adherence

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Furthermore, treatment with an antibiotic cocktail led to intestinal ecological dysregulation and induced colitis in mice, whereas supplementation with inulin-type fructans delayed the recovery of this antibiotic-induced intestinal inflammation and decreased the recovery of T reg and B cells in the lamina propria

Among these, alpha-linolenic acid (-LA, an -3) and linoleic acid (LA, an -6) are defined as essential fatty acids since they cannot be synthesized in human body, and their intake fully depends on the diet [119]