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- Kurt thought there was a 50% chance all GLP-1 compounding would end in the next 6 months (both 503A and 503B) - Did not mention direct communication from the FDA telling them to stop compounding GLP-1s - ProRx felt it was time to stop due to the end of the shortage in March 2025, and did not feel influenced by the April 1 FDA statement - Kurt thinks 503B production of GLP-1s are underreported and much larger than thought - 503As can't take care of the compounded GLP-1 market at their current capacity - We both have concerns about patient access without compounded GLP-1s and worry it will send more patients to the grey market for RUO injections that don't have the same level of sterility and regulation To view or add a comment, sign in Yesterday the FDA proposed removing GLP-1s from the 503B bulk list, and I spoke to Kurt Lunkwitz from ProRx to talk about changes to GLP-1 compounding

Similarly, standard oral capsules often have low bioavailability, meaning the body has a hard time absorbing them

Environmental factors: Infections: Bacterial and viral infections may trigger autoimmune responses

The addition of glucagon receptor agonism is a key distinguishing feature of the tri-agonist design

List of Sources Explore GLP-1 Medications: Mechanisms and Benefits Women in Menopause Benefit From GLP-1 Weight-Loss Medications as Much as Younger Women | Research | Advances in Endocrinology, and Womens Health | NewYork-Presbyterian ( cnn.com ( Weight loss drugs could be a gamechanger for women with a common hormonal disorder ( Study identifies benefits, risks linked to popular weight-loss drugs | WashU Medicine ( GLP-1 Receptor Agonists May Modestly Reduce Risk of Fourteen Obesity-Related Cancers for People with Diabetes ASCO ( Assess GLP-1 Costs Without Insurance: Key Factors Makers of Wegovy & Zepbound Cut Prices for Those Without Insurance ( healthline.com ( keckmedicine.org ( The cost of weight loss drugs is finally dropping