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Without adequate collagen production and proper organization of collagen fibers, wounds heal with reduced strength and may be more prone to reopening or developing problematic scars

Physiol Mol Biol Plants 32 , 961979 (2026)

292 , R1158R1164 (2007)

GCN2 promotes stress-response mechanisms, like autophagy, amino acid uptake, and the secretion of vascular endothelial growth factor (VEGF) with subsequent induction of angiogenesis for the acquisition of nutrients [150]

Ann Rheum Dis 76(8):14111419 Debbi EM, Agar G, Fichman G, Ziv YB, Kardosh R, Halperin N et al (2011) Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study