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Photodecaging of a Mitochondria-localized iridium(III) endoperoxide complex for two-photon photoactivated therapy under hypoxia
The 2016 Lee et al
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In human skin fibroblasts, Nrf2-driven antioxidant enzyme expression translated into: Reduced intracellular ROS Improved mitochondrial membrane potential Protection against senescence-associated cell damage [36] In human gingival and periodontal stem cells, Epitalon significantly reduced aging biomarkers such as p16 and p21, decreased ROS levels, and preserved mitochondrial function, even under stress [42]
In support of this hypothesis, we found that the Y1-R ligand, PYY 1-36 , inhibited Ex-4-mediated stimulatory responses
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