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It would also help explain a clinical observation discussed later: the gastrointestinal side effects associated with amylin analogs (nausea, early fullness) tend to be most pronounced during dose escalation and to ease with continued treatment, a pattern consistent with partial adaptation of the very gastric mechanism in question

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The overall tumor response rate was 58% by CT RESIST criteria (five tumors demonstrated a complete response and 10 had partial)

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