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Minimal model analysis using a frequently sampled intravenous glucose tolerance test (FSIGT) is an alternative to the simplified clamp procedure for assessing insulin secretion in insulin sensitivity experiments [129]

A 68-week trial published in the New England Journal of Medicine showed that participants taking semaglutide lost an average of 14% of their body weight, compared to a 3% loss in the placebo group

This means you don't feel as hungry and you eat less

Because of these changes, many clinicians encourage people using GLP-1 medications to be intentional about hydration , rather than relying only on thirst cues

However, GLP-1 agonist drugs are associated with some common adverse effects