Patients with T2DM initiating GLP-1 RAs or metformin as first-line monotherapy were included (87,229 matched patients per cohort).The researchers found that compared with metformin, GLP-1 RA use was associated with a significantly lower risk for overall dementia, Alzheimer disease, and nonvascular dementias (adjusted hazard ratios, 0.90, 0.88, and 0.75, respectively)
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[DOI] [PubMed] [Google Scholar] 118.Stagnaro-Green A, Abalovich M, Alexander E, et al
While both medications exhibit strong weight-loss potential, Tirzepatides dual-action mechanism (GLP-1 and GIP) may contribute to slightly greater outcomes in clinical trials
This implies that smoking cigarettes is an effective promoter for abnormal IL-8 secretion in COPD passageways [221]